Sprained left ankle will keep him out for a second straight game. Lions quarterback Matthew Stafford, the league highest paid player, was in midseason form in Detroit 35 23 season opening win over Arizona with 292 yards passing and four touchdowns while engineering his 27th fourth quarter or overtime comeback since 2011.Tom Brady, Patriots, threw three touchdown passes in the first quarter for the first time in his career, eclipsed 300 yards passing in the first half for only the second time, and New England scored 30 first half points en route to a 36 20 victory over the winless Saints. He finished 30 of 39 for 447 yards.Trevor Siemian, Broncos, tied a career high with four touchdown passes in Denver 42 17 blowout of the Dallas Cowboys.Joe Flacco, Ravens, went 25 for 34 for 217 yards with a pair of touchdown passes and Baltimore breezed past Cleveland 24 10.Drew Brees, Saints, passed for 356 yards and two TDs in New Orleans 36 20 loss to New England.Carson Wentz, Eagles, threw for 333 yards and two touchdowns, but his Hail Mary pass bounced off the hands of a couple defenders and fell incomplete as time expired in Philadelphia 27 20 loss at Kansas City.Derek Carr, Raiders, had three touchdown passes to Michael Crabtree in Oakland 45 20 rout of the New York Jets.Aaron Rodgers, Packers, passed for 343 yards and two TDs reaching 400 for his career in Green Bay 34 23 loss at Atlanta.Carlos Hyde, 49ers, ran for 124 yards on 15 carries in San Francisco 12 9 loss at Seattle.Jay Ajayi, Dolphins, had 122 yards rushing on 28 carries in Miami 19 17 victory over the Los Angeles Chargers.Derrick Henry, Titans, finished with a career high 92 yards rushing, including 87 in the final two quarters of Tennessee 37 16 win at Jacksonville.Devonta Freeman, Falcons, ran for two touchdowns and finished with 84 yards in Atlanta 34 23 win over Green Bay.Le Bell, Steelers, had 87 yards rushing on 27 carries in Pittsburgh 26 9 win over Minnesota, his second game since ending a summer long sabbatical due to a contract dispute.Chris Thompson, Redskins, had two touchdown runs and finished with 77 yards rushing on just three carries in Washington 27 20 win at the Los Angeles Rams..

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